FTSJ1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FTSJ1 at tissue level.

III. Associated gene sets

GO_0030488Biological processtRNA methylation
GO_0002181Biological processcytoplasmic translation
GO_0022008Biological processneurogenesis
GO_0006400Biological processtRNA modification
GO_0002130Biological processwobble position ribose methylation
GO_0002128Biological processtRNA nucleoside ribose methylation
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0106339Molecular functiontRNA (cytidine(32)-2'-O)-methyltransferase activity
GO_0016423Molecular functiontRNA (guanine) methyltransferase activity
GO_0106340Molecular functiontRNA (guanine(34)-2'-O)-methyltransferase activity
GO_0008175Molecular functiontRNA methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0106050Molecular functiontRNA 2'-O-methyltransferase activity

IV. Literature review

[source]
Gene nameFTSJ1
Protein nametRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1)
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1)
tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205)
FtsJ RNA 2'-O-methyltransferase 1 (cDNA FLJ52916, highly similar to ribosomal RNA methyltransferase 1)
SynonymsJM23
DescriptionFUNCTION: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs . Requisite for faithful cytoplasmic translation . Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs . Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs . Promotes translation efficiency of the UUU codon . Plays a role in neurogenesis . Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis . Requisite for RNA-mediated gene silencing . May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) . .

FUNCTION: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. .

FUNCTION: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. .

AccessionsENST00000348411.3 [Q9UET6-1]
A0A024QYX5
A0A0S2Z5C9
ENST00000019019.6 [Q9UET6-2]
B3KN91
B7Z4K4
ENST00000396894.8
Q9UET6