Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 6 studies | 20% ± 4% | |
pro-B cell | 5 studies | 29% ± 9% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 19% ± 4% | |
plasmacytoid dendritic cell | 5 studies | 23% ± 6% | |
precursor B cell | 4 studies | 24% ± 3% | |
conventional dendritic cell | 3 studies | 22% ± 4% | |
fibroblast | 3 studies | 19% ± 4% | |
epithelial cell | 3 studies | 30% ± 9% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 5% | |
basal cell | 3 studies | 18% ± 1% | |
CD8-positive, alpha-beta T cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 3 studies | 17% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2996.64 | 1445 / 1445 | 100% | 54.37 | 183 / 183 |
liver | 100% | 4907.35 | 226 / 226 | 100% | 43.62 | 406 / 406 |
ovary | 100% | 9320.54 | 180 / 180 | 100% | 72.26 | 430 / 430 |
pancreas | 100% | 2309.98 | 328 / 328 | 100% | 57.06 | 178 / 178 |
thymus | 100% | 3905.91 | 653 / 653 | 100% | 60.67 | 604 / 605 |
lung | 100% | 4726.94 | 578 / 578 | 100% | 51.58 | 1153 / 1155 |
intestine | 100% | 2859.06 | 966 / 966 | 100% | 61.80 | 525 / 527 |
skin | 100% | 2589.38 | 1805 / 1809 | 100% | 40.02 | 471 / 472 |
uterus | 100% | 4958.22 | 170 / 170 | 100% | 58.64 | 457 / 459 |
prostate | 100% | 4159.38 | 245 / 245 | 99% | 57.15 | 499 / 502 |
stomach | 100% | 2883.47 | 359 / 359 | 99% | 53.86 | 284 / 286 |
kidney | 100% | 3168.71 | 89 / 89 | 99% | 32.22 | 894 / 901 |
adrenal gland | 100% | 6605.87 | 258 / 258 | 99% | 34.76 | 228 / 230 |
bladder | 100% | 3665.76 | 21 / 21 | 99% | 56.57 | 499 / 504 |
breast | 100% | 4526.68 | 459 / 459 | 99% | 49.25 | 1105 / 1118 |
brain | 97% | 1528.28 | 2563 / 2642 | 100% | 41.53 | 705 / 705 |
adipose | 100% | 4945.30 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 42.17 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 103.87 | 29 / 29 |
spleen | 100% | 4298.43 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 59.29 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 77.75 | 1 / 1 |
blood vessel | 100% | 3810.12 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 3462.00 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 2561.93 | 838 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 83% | 2050.28 | 770 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006139 | Biological process | nucleobase-containing compound metabolic process |
GO_0046655 | Biological process | folic acid metabolic process |
GO_0006536 | Biological process | glutamate metabolic process |
GO_0006760 | Biological process | folic acid-containing compound metabolic process |
GO_0006730 | Biological process | one-carbon metabolic process |
GO_0046901 | Biological process | tetrahydrofolylpolyglutamate biosynthetic process |
GO_0001889 | Biological process | liver development |
GO_0031100 | Biological process | animal organ regeneration |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0004326 | Molecular function | tetrahydrofolylpolyglutamate synthase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | FPGS |
Protein name | Folylpolyglutamate synthetase mitochondrial isoform (EC 6.3.2.17) Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) Folylpolyglutamate synthetase cytosolic isoform (EC 6.3.2.17) Folylpolyglutamate synthase Alternative protein FPGS |
Synonyms | |
Description | FUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. . |
Accessions | L8E999 Q05932 ENST00000373247.7 [Q05932-1] Q5JU20 Q96LE3 ENST00000630236.2 ENST00000431857.5 Q96LE4 ENST00000423577.1 Q96DJ7 Q5JU21 ENST00000373225.7 [Q05932-3] Q96DJ6 ENST00000393706.6 [Q05932-4] ENST00000373228.5 Q5JU23 |