FPGS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0046655Biological processfolic acid metabolic process
GO_0006536Biological processglutamate metabolic process
GO_0006760Biological processfolic acid-containing compound metabolic process
GO_0006730Biological processone-carbon metabolic process
GO_0046901Biological processtetrahydrofolylpolyglutamate biosynthetic process
GO_0001889Biological processliver development
GO_0031100Biological processanimal organ regeneration
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0004326Molecular functiontetrahydrofolylpolyglutamate synthase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameFPGS
Protein nameFolylpolyglutamate synthetase mitochondrial isoform (EC 6.3.2.17)
Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)
Folylpolyglutamate synthetase cytosolic isoform (EC 6.3.2.17)
Folylpolyglutamate synthase
Alternative protein FPGS
Synonyms
DescriptionFUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. .

AccessionsL8E999
Q05932
ENST00000373247.7 [Q05932-1]
Q5JU20
Q96LE3
ENST00000630236.2
ENST00000431857.5
Q96LE4
ENST00000423577.1
Q96DJ7
Q5JU21
ENST00000373225.7 [Q05932-3]
Q96DJ6
ENST00000393706.6 [Q05932-4]
ENST00000373228.5
Q5JU23