FNDC4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FNDC4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FNDC4 at tissue level.

III. Associated gene sets

GO_0050728Biological processnegative regulation of inflammatory response
GO_0071559Biological processresponse to transforming growth factor beta
GO_0005615Cellular componentextracellular space
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane

IV. Literature review

[source]
Gene nameFNDC4
Protein nameFibronectin type III domain-containing protein 4 (Fibronectin type III repeat-containing protein 1)
SynonymsFRCP1
UNQ6389/PRO21134
DescriptionFUNCTION: Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. .

AccessionsENST00000264703.4
Q9H6D8