FMO1 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell of proximal tubule	7 studies	28% ± 9%	Explore
fibroblast	3 studies	16% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of FMO1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	99%	3518.88	88 / 89	84%	55.92	757 / 901
breast	97%	672.16	445 / 459	80%	7.87	889 / 1118
pancreas	68%	106.40	222 / 328	75%	5.58	134 / 178
ovary	97%	448.08	174 / 180	46%	3.54	198 / 430
skin	85%	466.75	1541 / 1809	47%	3.56	220 / 472
uterus	81%	239.33	138 / 170	42%	4.36	194 / 459
lung	50%	127.13	290 / 578	60%	5.33	691 / 1155
thymus	93%	288.88	607 / 653	14%	1.42	84 / 605
esophagus	60%	176.73	864 / 1445	46%	3.37	84 / 183
adrenal gland	95%	479.42	246 / 258	10%	1.24	22 / 230
adipose	93%	555.20	1124 / 1204	0%	0	0 / 0
stomach	48%	69.22	174 / 359	28%	1.88	81 / 286
bladder	43%	44.57	9 / 21	26%	1.57	131 / 504
tonsil	0%	0	0 / 0	67%	6.08	30 / 45
lymph node	0%	0	0 / 0	59%	4.42	17 / 29
liver	13%	15.64	29 / 226	32%	4.90	129 / 406
intestine	27%	201.78	264 / 966	17%	1.01	88 / 527
prostate	26%	25.93	64 / 245	2%	0.05	8 / 502
heart	21%	30.33	177 / 861	0%	0	0 / 0
blood vessel	18%	30.66	244 / 1335	0%	0	0 / 0
brain	0%	0.44	9 / 2642	3%	0.24	22 / 705
muscle	2%	2.57	13 / 803	0%	0	0 / 0
peripheral blood	0%	0.75	4 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0097009	Biological process	energy homeostasis
GO_0070995	Biological process	NADPH oxidation
GO_0000098	Biological process	sulfur amino acid catabolic process
GO_0006805	Biological process	xenobiotic metabolic process
GO_0009404	Biological process	toxin metabolic process
GO_0042412	Biological process	taurine biosynthetic process
GO_0006082	Biological process	organic acid metabolic process
GO_0046322	Biological process	negative regulation of fatty acid oxidation
GO_0032496	Biological process	response to lipopolysaccharide
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0047822	Molecular function	hypotaurine dehydrogenase activity
GO_0034899	Molecular function	trimethylamine monooxygenase activity
GO_0050661	Molecular function	NADP binding
GO_0004499	Molecular function	N,N-dimethylaniline monooxygenase activity
GO_0004497	Molecular function	monooxygenase activity
GO_0005515	Molecular function	protein binding
GO_0050660	Molecular function	flavin adenine dinucleotide binding

Gene name	FMO1
Protein name	Alternative protein FMO1 Flavin-containing monooxygenase (EC 1.-.-.-) Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase)
Synonyms
Description	FUNCTION: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics . Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes . In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity). .
Accessions	A0A1W2PNR8 ENST00000469112.5 ENST00000402921.6 [Q01740-2] ENST00000354841.4 [Q01740-1] L8E7C3 ENST00000617670.6 [Q01740-1] Q01740 ENST00000367750.7 [Q01740-1]

FMO1 report