FMNL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046847Biological processfilopodium assembly
GO_0008360Biological processregulation of cell shape
GO_0001525Biological processangiogenesis
GO_0030036Biological processactin cytoskeleton organization
GO_0007010Biological processcytoskeleton organization
GO_0030866Biological processcortical actin cytoskeleton organization
GO_0016477Biological processcell migration
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0051015Molecular functionactin filament binding
GO_0032794Molecular functionGTPase activating protein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameFMNL3
Protein nameFMNL3 protein
Formin like 3
Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)
SynonymsKIAA2014
FRL2
FHOD3
WBP3
DescriptionFUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. .

AccessionsENST00000335154.10 [Q8IVF7-3]
Q8N4Y7
F8W1F5
F8VYL1
Q8IVF7
ENST00000550488.5
ENST00000550424.1
ENST00000352151.9 [Q8IVF7-2]