FLVCR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046620Biological processregulation of organ growth
GO_0043249Biological processerythrocyte maturation
GO_0001701Biological processin utero embryonic development
GO_0055085Biological processtransmembrane transport
GO_0015886Biological processheme transport
GO_0048704Biological processembryonic skeletal system morphogenesis
GO_0042733Biological processembryonic digit morphogenesis
GO_0006839Biological processmitochondrial transport
GO_0035264Biological processmulticellular organism growth
GO_0006783Biological processheme biosynthetic process
GO_0048536Biological processspleen development
GO_0030218Biological processerythrocyte differentiation
GO_0006879Biological processintracellular iron ion homeostasis
GO_0001568Biological processblood vessel development
GO_0097037Biological processheme export
GO_0060323Biological processhead morphogenesis
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0015232Molecular functionheme transmembrane transporter activity
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFLVCR1
Protein nameFLVCR heme transporter 1
Heme transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (hFLVCR)
SynonymsFLVCR
DescriptionFUNCTION: [Isoform 1]: Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. .; FUNCTION: [Isoform 1]: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. .; FUNCTION: [Isoform 2]: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. .

AccessionsH7C3Z2
ENST00000419102.1
Q9Y5Y0
ENST00000366971.9 [Q9Y5Y0-1]