FITM2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FITM2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FITM2 at tissue level.

III. Associated gene sets

GO_0022604Biological processregulation of cell morphogenesis
GO_0030730Biological processsequestering of triglyceride
GO_0010890Biological processpositive regulation of sequestering of triglyceride
GO_0008654Biological processphospholipid biosynthetic process
GO_0055088Biological processlipid homeostasis
GO_0140042Biological processlipid droplet formation
GO_0019915Biological processlipid storage
GO_0007010Biological processcytoskeleton organization
GO_0034389Biological processlipid droplet organization
GO_0010866Biological processregulation of triglyceride biosynthetic process
GO_0036115Biological processfatty-acyl-CoA catabolic process
GO_0035356Biological processintracellular triglyceride homeostasis
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0017129Molecular functiontriglyceride binding
GO_0010945Molecular functioncoenzyme A diphosphatase activity
GO_0005515Molecular functionprotein binding
GO_0019992Molecular functiondiacylglycerol binding

IV. Literature review

[source]
Gene nameFITM2
Protein nameAcyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2)
SynonymsFIT2
C20orf142
DescriptionFUNCTION: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). .

AccessionsQ8N6M3
ENST00000396825.4