FIRRM | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	26% ± 9%	Explore
glutamatergic neuron	3 studies	32% ± 8%	Explore

Name	Number of supported studies	Average coverage
brain	4 studies	25% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	245.94	1444 / 1445	97%	6.78	178 / 183
breast	100%	328.27	459 / 459	96%	7.76	1074 / 1118
uterus	100%	367.67	170 / 170	94%	7.92	432 / 459
stomach	100%	188.33	359 / 359	93%	5.54	266 / 286
intestine	100%	270.35	966 / 966	93%	5.28	489 / 527
lung	99%	220.56	574 / 578	93%	6.00	1074 / 1155
bladder	100%	275.29	21 / 21	92%	6.57	464 / 504
skin	100%	363.00	1806 / 1809	90%	6.07	427 / 472
ovary	100%	358.60	180 / 180	86%	4.69	371 / 430
pancreas	96%	113.84	314 / 328	70%	2.69	124 / 178
brain	93%	169.34	2462 / 2642	72%	2.92	509 / 705
thymus	100%	282.08	653 / 653	54%	2.05	324 / 605
liver	97%	178.00	219 / 226	53%	2.65	216 / 406
prostate	100%	279.12	245 / 245	47%	1.32	238 / 502
kidney	97%	146.67	86 / 89	33%	0.95	297 / 901
adrenal gland	98%	186.73	252 / 258	11%	0.36	25 / 230
spleen	100%	325.15	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	8.88	45 / 45
ureter	0%	0	0 / 0	100%	2.83	1 / 1
blood vessel	100%	219.92	1333 / 1335	0%	0	0 / 0
adipose	100%	279.83	1202 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	7.21	27 / 29
heart	89%	111.79	769 / 861	0%	0	0 / 0
peripheral blood	85%	380.52	792 / 929	0%	0	0 / 0
muscle	83%	85.09	668 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	25%	0.59	20 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0045859	Biological process	regulation of protein kinase activity
GO_0036297	Biological process	interstrand cross-link repair
GO_0000278	Biological process	mitotic cell cycle
GO_0007059	Biological process	chromosome segregation
GO_0000775	Cellular component	chromosome, centromeric region
GO_0000776	Cellular component	kinetochore
GO_0030496	Cellular component	midbody
GO_0051233	Cellular component	spindle midzone
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding

Gene name	FIRRM
Protein name	FIGNL1-interacting regulator of recombination and mitosis (FIDGETIN-like-1 interacting protein) (FLIP) (POLO1-associating protein) Chromosome 1 open reading frame 112
Synonyms	APOLO1 C1orf112
Description	FUNCTION: Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities . Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis . In complex with FIGL1 may regulate homologous recombination . .
Accessions	ENST00000413811.3 [Q9NSG2-3] ENST00000459772.5 ENST00000481744.5 A0A1B0GV14 ENST00000359326.9 [Q9NSG2-1] A0A1B0GUP7 ENST00000472795.5 Q9NSG2 ENST00000496973.5 ENST00000466580.6 A0A1B0GTJ9 ENST00000286031.10 [Q9NSG2-1]

FIRRM report