Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 7 studies | 26% ± 6% | |
microglial cell | 5 studies | 24% ± 5% | |
glutamatergic neuron | 5 studies | 48% ± 23% | |
endothelial cell | 4 studies | 24% ± 10% | |
neuron | 4 studies | 21% ± 8% | |
GABAergic neuron | 4 studies | 42% ± 16% | |
astrocyte | 4 studies | 31% ± 12% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 7% | |
monocyte | 4 studies | 22% ± 6% | |
oligodendrocyte | 4 studies | 26% ± 8% | |
epithelial cell | 3 studies | 19% ± 3% | |
alveolar macrophage | 3 studies | 35% ± 12% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 6 studies | 37% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1750.52 | 2639 / 2642 | 100% | 3.80 | 705 / 705 |
breast | 100% | 1217.64 | 459 / 459 | 99% | 4.42 | 1108 / 1118 |
thymus | 100% | 1190.75 | 653 / 653 | 99% | 3.29 | 598 / 605 |
prostate | 100% | 1158.07 | 245 / 245 | 98% | 2.86 | 493 / 502 |
pancreas | 99% | 598.50 | 324 / 328 | 98% | 2.38 | 175 / 178 |
kidney | 100% | 1060.02 | 89 / 89 | 97% | 2.78 | 873 / 901 |
lung | 100% | 1452.27 | 578 / 578 | 96% | 2.37 | 1113 / 1155 |
bladder | 100% | 1279.76 | 21 / 21 | 96% | 2.68 | 484 / 504 |
adrenal gland | 100% | 1428.62 | 258 / 258 | 95% | 2.74 | 219 / 230 |
ovary | 100% | 1125.27 | 180 / 180 | 95% | 2.36 | 407 / 430 |
uterus | 100% | 1267.86 | 170 / 170 | 95% | 2.44 | 434 / 459 |
stomach | 100% | 987.20 | 359 / 359 | 94% | 2.16 | 269 / 286 |
skin | 100% | 1061.48 | 1808 / 1809 | 93% | 2.77 | 441 / 472 |
intestine | 100% | 1368.55 | 966 / 966 | 93% | 2.09 | 492 / 527 |
esophagus | 100% | 1242.49 | 1445 / 1445 | 93% | 1.89 | 170 / 183 |
liver | 95% | 399.35 | 214 / 226 | 43% | 0.69 | 175 / 406 |
adipose | 100% | 1235.50 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1758.26 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 3.47 | 29 / 29 |
spleen | 100% | 1932.73 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.08 | 1 / 1 |
muscle | 100% | 879.36 | 801 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 1399.45 | 911 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 2.16 | 43 / 45 |
heart | 95% | 635.78 | 821 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 75% | 2.44 | 60 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031642 | Biological process | negative regulation of myelination |
GO_0032288 | Biological process | myelin assembly |
GO_0046856 | Biological process | phosphatidylinositol dephosphorylation |
GO_0007033 | Biological process | vacuole organization |
GO_0036092 | Biological process | phosphatidylinositol-3-phosphate biosynthetic process |
GO_0048666 | Biological process | neuron development |
GO_0043473 | Biological process | pigmentation |
GO_0007626 | Biological process | locomotory behavior |
GO_0006661 | Biological process | phosphatidylinositol biosynthetic process |
GO_0031902 | Cellular component | late endosome membrane |
GO_0005811 | Cellular component | lipid droplet |
GO_0031901 | Cellular component | early endosome membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0010008 | Cellular component | endosome membrane |
GO_0034485 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
GO_0004439 | Molecular function | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0043813 | Molecular function | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
Gene name | FIG4 |
Protein name | FIG4 phosphoinositide 5-phosphatase Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16) |
Synonyms | SAC3 KIAA0274 |
Description | FUNCTION: Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate . Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production . In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro . . |
Accessions | ENST00000674930.1 ENST00000674649.1 ENST00000674571.1 ENST00000675887.1 ENST00000674884.1 A0A6Q8PHC7 ENST00000674569.1 ENST00000675844.1 Q92562 A0A6Q8PGW5 ENST00000675994.1 ENST00000368941.2 A0A6Q8PGP1 A0A6Q8PF04 ENST00000675879.1 ENST00000676037.1 A0A6Q8PG61 Q5TCS4 H0Y6G7 ENST00000675523.1 A0A6Q8PHA1 ENST00000676021.1 ENST00000675973.1 ENST00000674744.1 A0A6Q8PGY4 A0A6Q8PGY7 A0A6Q8PF62 ENST00000674956.1 A0A6Q8PGB4 ENST00000675096.1 ENST00000230124.8 ENST00000674783.1 ENST00000674933.1 A0A6Q8PHH5 ENST00000454215.6 ENST00000674657.1 ENST00000674557.1 A0A6Q8PGW0 A0A6Q8PHK3 ENST00000675153.1 ENST00000675831.1 A0A6Q8PHP5 ENST00000675606.1 A0A6Q8PH92 ENST00000676442.1 A0A6Q8PHM5 A0A6Q8PF27 ENST00000674575.1 ENST00000675681.1 A0A6Q8PF70 A0A6Q8PFJ3 ENST00000675726.1 ENST00000675714.1 ENST00000675122.1 A0A6Q8PGP4 ENST00000674641.1 ENST00000675991.1 A0A6Q8PHB4 ENST00000675552.1 A0A6Q8PG59 ENST00000675772.1 A0A6Q8PG49 A0A6Q8PGL0 ENST00000675009.1 Q5TCS5 ENST00000675284.1 ENST00000675311.1 ENST00000675004.1 A0A6Q8PFK7 A0A6Q8PF90 A0A6Q8PF86 ENST00000675426.1 ENST00000415980.2 ENST00000674644.1 ENST00000674778.1 ENST00000676435.1 A0A6Q8PGM1 A0A6Q8PGC1 |