FIG4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031642Biological processnegative regulation of myelination
GO_0032288Biological processmyelin assembly
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0007033Biological processvacuole organization
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0048666Biological processneuron development
GO_0043473Biological processpigmentation
GO_0007626Biological processlocomotory behavior
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0031902Cellular componentlate endosome membrane
GO_0005811Cellular componentlipid droplet
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0034485Molecular functionphosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO_0004439Molecular functionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0043813Molecular functionphosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

IV. Literature review

[source]
Gene nameFIG4
Protein nameFIG4 phosphoinositide 5-phosphatase
Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16)
SynonymsSAC3
KIAA0274
DescriptionFUNCTION: Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate . Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production . In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro . .

AccessionsENST00000674930.1
ENST00000674649.1
ENST00000674571.1
ENST00000675887.1
ENST00000674884.1
A0A6Q8PHC7
ENST00000674569.1
ENST00000675844.1
Q92562
A0A6Q8PGW5
ENST00000675994.1
ENST00000368941.2
A0A6Q8PGP1
A0A6Q8PF04
ENST00000675879.1
ENST00000676037.1
A0A6Q8PG61
Q5TCS4
H0Y6G7
ENST00000675523.1
A0A6Q8PHA1
ENST00000676021.1
ENST00000675973.1
ENST00000674744.1
A0A6Q8PGY4
A0A6Q8PGY7
A0A6Q8PF62
ENST00000674956.1
A0A6Q8PGB4
ENST00000675096.1
ENST00000230124.8
ENST00000674783.1
ENST00000674933.1
A0A6Q8PHH5
ENST00000454215.6
ENST00000674657.1
ENST00000674557.1
A0A6Q8PGW0
A0A6Q8PHK3
ENST00000675153.1
ENST00000675831.1
A0A6Q8PHP5
ENST00000675606.1
A0A6Q8PH92
ENST00000676442.1
A0A6Q8PHM5
A0A6Q8PF27
ENST00000674575.1
ENST00000675681.1
A0A6Q8PF70
A0A6Q8PFJ3
ENST00000675726.1
ENST00000675714.1
ENST00000675122.1
A0A6Q8PGP4
ENST00000674641.1
ENST00000675991.1
A0A6Q8PHB4
ENST00000675552.1
A0A6Q8PG59
ENST00000675772.1
A0A6Q8PG49
A0A6Q8PGL0
ENST00000675009.1
Q5TCS5
ENST00000675284.1
ENST00000675311.1
ENST00000675004.1
A0A6Q8PFK7
A0A6Q8PF90
A0A6Q8PF86
ENST00000675426.1
ENST00000415980.2
ENST00000674644.1
ENST00000674778.1
ENST00000676435.1
A0A6Q8PGM1
A0A6Q8PGC1