FEM1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFEM1C
Protein nameProtein fem-1 homolog C (FEM1c) (FEM1-gamma)
SynonymsKIAA1785
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation . The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding . Promotes ubiquitination and degradation of SLBP . .

AccessionsENST00000274457.5
Q96JP0