FEM1A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FEM1A at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0050729Biological processpositive regulation of inflammatory response
GO_0050728Biological processnegative regulation of inflammatory response
GO_0051438Biological processregulation of ubiquitin-protein transferase activity
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005739Cellular componentmitochondrion
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0031867Molecular functionEP4 subtype prostaglandin E2 receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFEM1A
Protein nameProtein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein)
SynonymsEPRAP
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation . Promotes ubiquitination and degradation of SLBP . Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity). .

AccessionsQ9BSK4
ENST00000269856.5