FDX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FDX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FDX2 at tissue level.

III. Associated gene sets

GO_0022900Biological processelectron transport chain
GO_0016226Biological processiron-sulfur cluster assembly
GO_0140647Biological processP450-containing electron transport chain
GO_0044572Biological process[4Fe-4S] cluster assembly
GO_0044571Biological process[2Fe-2S] cluster assembly
GO_1990229Cellular componentiron-sulfur cluster assembly complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0051537Molecular function2 iron, 2 sulfur cluster binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0009055Molecular functionelectron transfer activity

IV. Literature review

[source]
Gene nameFDX2
Protein nameFerredoxin-2, mitochondrial (Adrenodoxin-like protein) (Ferredoxin-1-like protein)
Ferredoxin 2
SynonymsFDX1L
DescriptionFUNCTION: Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU . The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). .

AccessionsA0A0A0MTS8
ENST00000494368.5
A0A9L9PXQ6
ENST00000492239.5
Q6P4F2
ENST00000393708.3 [Q6P4F2-1]
ENST00000706663.1