I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 9 studies | 26% ± 9% | |
| glutamatergic neuron | 4 studies | 31% ± 14% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 9 studies | 26% ± 9% | |
| glutamatergic neuron | 4 studies | 31% ± 14% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 29% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 2130.80 | 2636 / 2642 | 96% | 8.52 | 679 / 705 |
| lung | 92% | 547.90 | 533 / 578 | 84% | 7.12 | 972 / 1155 |
| ovary | 39% | 169.86 | 70 / 180 | 99% | 25.53 | 426 / 430 |
| skin | 71% | 1780.87 | 1293 / 1809 | 60% | 3.83 | 285 / 472 |
| intestine | 36% | 334.76 | 349 / 966 | 92% | 10.54 | 487 / 527 |
| bladder | 24% | 76.10 | 5 / 21 | 90% | 10.17 | 452 / 504 |
| stomach | 11% | 44.24 | 41 / 359 | 95% | 10.84 | 273 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 27.11 | 29 / 29 |
| spleen | 100% | 2177.79 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.69 | 1 / 1 |
| peripheral blood | 100% | 3201.70 | 925 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 1% | 4.65 | 4 / 328 | 90% | 7.73 | 160 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 5.90 | 37 / 45 |
| breast | 22% | 90.92 | 103 / 459 | 59% | 3.50 | 658 / 1118 |
| uterus | 4% | 13.41 | 7 / 170 | 75% | 6.42 | 345 / 459 |
| esophagus | 3% | 13.23 | 46 / 1445 | 74% | 6.97 | 135 / 183 |
| thymus | 9% | 78.60 | 57 / 653 | 65% | 6.04 | 394 / 605 |
| adrenal gland | 16% | 74.87 | 41 / 258 | 57% | 2.84 | 130 / 230 |
| kidney | 12% | 61.62 | 11 / 89 | 51% | 2.55 | 457 / 901 |
| adipose | 41% | 187.51 | 488 / 1204 | 0% | 0 | 0 / 0 |
| liver | 13% | 55.98 | 29 / 226 | 20% | 1.84 | 83 / 406 |
| prostate | 14% | 55.83 | 34 / 245 | 9% | 0.33 | 47 / 502 |
| eye | 0% | 0 | 0 / 0 | 16% | 0.54 | 13 / 80 |
| blood vessel | 7% | 36.22 | 100 / 1335 | 0% | 0 | 0 / 0 |
| heart | 1% | 4.53 | 11 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.59 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050870 | Biological process | positive regulation of T cell activation |
| GO_0072583 | Biological process | clathrin-dependent endocytosis |
| GO_0048268 | Biological process | clathrin coat assembly |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0005905 | Cellular component | clathrin-coated pit |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0030136 | Cellular component | clathrin-coated vesicle |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0035612 | Molecular function | AP-2 adaptor complex binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FCHO1 |
| Protein name | FCH and mu domain containing endocytic adaptor 1 FCH and mu domain containing endocytic adaptor 1 (FCH domain only 1, isoform CRA_b) F-BAR domain only protein 1 |
| Synonyms | KIAA0290 hCG_2000568 |
| Description | FUNCTION: Functions in an early step of clathrin-mediated endocytosis . Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation . Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation . . |
| Accessions | M0QXW2 ENST00000699216.1 ENST00000699207.1 [O14526-1] ENST00000600209.6 [O14526-1] ENST00000699176.1 [O14526-1] A0A8V8TMV7 ENST00000598067.6 ENST00000596309.5 ENST00000596536.6 [O14526-1] ENST00000593833.5 M0QZF0 ENST00000595549.5 ENST00000596462.6 M0QXY1 M0QYA9 ENST00000699205.1 A0A0C3SFZ9 ENST00000699201.1 ENST00000699198.1 A0A8V8TNC3 ENST00000699212.1 ENST00000699177.1 [O14526-1] M0QYN8 ENST00000594068.6 ENST00000699213.1 ENST00000597474.5 M0R3E5 ENST00000699202.1 ENST00000600209.5 A0A8V8TP96 ENST00000594202.6 O14526 M0QZI9 M0QZE1 M0QZS1 ENST00000699214.1 ENST00000699196.1 ENST00000699200.1 M0R0U5 ENST00000600676.5 [O14526-1] ENST00000699209.1 [O14526-1] ENST00000699215.1 [O14526-1] ENST00000596951.6 [O14526-1] ENST00000699203.1 ENST00000595033.5 [O14526-3] M0R3E7 ENST00000699197.1 ENST00000595023.5 ENST00000596507.6 ENST00000598086.5 A0A8V8TPN1 ENST00000593870.5 M0QY09 A0A8V8TPM7 ENST00000597718.6 ENST00000596865.6 ENST00000699208.1 A0A8V8TP91 ENST00000596309.6 [O14526-1] M0QYT8 ENST00000699210.1 ENST00000699199.1 ENST00000699206.1 M0QXD1 A0A8V8TMX9 A0A8V8TND1 A0A8V8TPA0 ENST00000598960.5 M0R1K4 ENST00000598539.6 M0R2J7 |
