FBXO43 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FBXO43 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXO43 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0051321Biological processmeiotic cell cycle
GO_0045835Biological processnegative regulation of meiotic nuclear division
GO_0010948Biological processnegative regulation of cell cycle process
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameFBXO43
Protein nameF-box protein 43
F-box only protein 43 (Endogenous meiotic inhibitor 2)
SynonymsEMI2
DescriptionFUNCTION: Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation . Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. .

AccessionsENST00000517806.5
E5RHI5
Q4G163
ENST00000428847.3