FBXL22 | OmnibusX

Name	Number of supported studies	Average coverage
smooth muscle cell	3 studies	24% ± 8%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXL22 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	92%	1122.56	226 / 245	97%	3.76	488 / 502
ovary	51%	249.55	92 / 180	81%	1.95	347 / 430
bladder	95%	1541.86	20 / 21	36%	0.94	182 / 504
uterus	96%	2568.42	164 / 170	33%	3.08	151 / 459
esophagus	78%	1017.96	1132 / 1445	38%	0.67	69 / 183
intestine	80%	1944.34	768 / 966	34%	0.68	181 / 527
ureter	0%	0	0 / 0	100%	2.89	1 / 1
blood vessel	98%	1550.91	1311 / 1335	0%	0	0 / 0
stomach	51%	564.03	183 / 359	47%	1.46	134 / 286
thymus	22%	46.90	144 / 653	70%	1.77	422 / 605
brain	22%	50.16	589 / 2642	67%	1.26	472 / 705
breast	29%	77.69	133 / 459	60%	1.14	668 / 1118
heart	85%	596.54	733 / 861	0%	0	0 / 0
pancreas	0%	0.48	1 / 328	46%	0.96	81 / 178
lung	11%	26.04	66 / 578	26%	0.71	301 / 1155
adipose	26%	115.38	318 / 1204	0%	0	0 / 0
skin	8%	21.06	151 / 1809	16%	0.25	75 / 472
kidney	7%	14.33	6 / 89	16%	0.25	140 / 901
muscle	15%	35.47	119 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	13%	0.15	10 / 80
adrenal gland	1%	3.54	3 / 258	8%	0.12	18 / 230
lymph node	0%	0	0 / 0	7%	0.09	2 / 29
tonsil	0%	0	0 / 0	7%	0.10	3 / 45
liver	0%	0	0 / 226	3%	0.04	13 / 406
spleen	3%	6.17	7 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0016567	Biological process	protein ubiquitination
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005730	Cellular component	nucleolus
GO_0005829	Cellular component	cytosol
GO_0030018	Cellular component	Z disc
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding

Gene name	FBXL22
Protein name	F-box and leucine rich repeat protein 22 F-box and leucine-rich protein 22
Synonyms
Description	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). .
Accessions	ENST00000638704.2 ENST00000360587.2 H0YMQ4 ENST00000560325.1 ENST00000534939.2 R4GNI3 A0A1W2PQW8 Q6P050

FBXL22 report