I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| squamous epithelial cell | 4 studies | 44% ± 23% | |
| epithelial cell | 3 studies | 42% ± 22% | |
| basal cell | 3 studies | 54% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| squamous epithelial cell | 4 studies | 44% ± 23% | |
| epithelial cell | 3 studies | 42% ± 22% | |
| basal cell | 3 studies | 54% ± 17% |
Insufficient scRNA-seq data for expression of FAM83A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 47% | 5624.63 | 672 / 1445 | 71% | 65.95 | 130 / 183 |
| lung | 23% | 28.98 | 133 / 578 | 70% | 56.17 | 814 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 62.70 | 38 / 45 |
| skin | 70% | 665.53 | 1272 / 1809 | 8% | 2.01 | 36 / 472 |
| bladder | 24% | 253.29 | 5 / 21 | 53% | 48.53 | 265 / 504 |
| uterus | 6% | 113.32 | 11 / 170 | 65% | 69.93 | 300 / 459 |
| pancreas | 2% | 4.58 | 7 / 328 | 62% | 28.74 | 111 / 178 |
| ovary | 5% | 4.13 | 9 / 180 | 48% | 11.39 | 205 / 430 |
| thymus | 36% | 33.19 | 237 / 653 | 15% | 2.66 | 89 / 605 |
| adrenal gland | 42% | 88.40 | 108 / 258 | 3% | 1.66 | 7 / 230 |
| peripheral blood | 29% | 113.37 | 274 / 929 | 0% | 0 | 0 / 0 |
| prostate | 27% | 103.96 | 67 / 245 | 0% | 0 | 0 / 502 |
| intestine | 12% | 21.80 | 114 / 966 | 12% | 6.25 | 65 / 527 |
| breast | 10% | 9.88 | 46 / 459 | 13% | 3.76 | 146 / 1118 |
| liver | 18% | 15.91 | 40 / 226 | 2% | 0.39 | 7 / 406 |
| stomach | 1% | 16.76 | 4 / 359 | 12% | 2.24 | 34 / 286 |
| adipose | 8% | 11.47 | 91 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 7% | 5.85 | 17 / 241 | 0% | 0 | 0 / 0 |
| kidney | 6% | 15.73 | 5 / 89 | 1% | 0.41 | 11 / 901 |
| heart | 2% | 2.06 | 21 / 861 | 0% | 0 | 0 / 0 |
| muscle | 1% | 2.19 | 9 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 1.27 | 14 / 1335 | 0% | 0 | 0 / 0 |
| brain | 1% | 0.45 | 14 / 2642 | 0% | 0 | 0 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0036312 | Molecular function | phosphatidylinositol 3-kinase regulatory subunit binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FAM83A |
| Protein name | Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) |
| Synonyms | TSGP |
| Description | FUNCTION: Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. . |
| Accessions | ENST00000536633.2 [Q86UY5-3] ENST00000276699.10 [Q86UY5-3] ENST00000690554.1 [Q86UY5-1] ENST00000518448.5 [Q86UY5-1] Q86UY5 ENST00000522648.5 [Q86UY5-2] |
