FAM20C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036179Biological processosteoclast maturation
GO_0097187Biological processdentinogenesis
GO_0043687Biological processpost-translational protein modification
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0071895Biological processodontoblast differentiation
GO_0031214Biological processbiomineral tissue development
GO_0019538Biological processprotein metabolic process
GO_0070166Biological processenamel mineralization
GO_0040036Biological processregulation of fibroblast growth factor receptor signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0051174Biological processregulation of phosphorus metabolic process
GO_0030501Biological processpositive regulation of bone mineralization
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0002020Molecular functionprotease binding
GO_0030145Molecular functionmanganese ion binding
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFAM20C
Protein nameExtracellular serine/threonine protein kinase FAM20C
Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)
SynonymsDMP4
DescriptionFUNCTION: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth . Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome . Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity . Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding . During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone . This is critical to maintain ER proteostasis and reduce cell death under ER stress . Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response . Required for osteoblast differentiation and mineralization . Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1/OPN . In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion . .

AccessionsQ8IXL6
ENST00000313766.6 [Q8IXL6-1]
A0A0G2JQD6
ENST00000672066.1 [Q8IXL6-1]
ENST00000630666.1
ENST00000633408.1