FAM20B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030166Biological processproteoglycan biosynthetic process
GO_0006468Biological processprotein phosphorylation
GO_0000139Cellular componentGolgi membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005515Molecular functionprotein binding
GO_0016773Molecular functionphosphotransferase activity, alcohol group as acceptor
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity

IV. Literature review

[source]
Gene nameFAM20B
Protein nameFAM20B glycosaminoglycan xylosylkinase
Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Xylose kinase)
SynonymsKIAA0475
DescriptionFUNCTION: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. .

AccessionsO75063
X6RH03
ENST00000440702.5
ENST00000263733.5