FAAH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0052651Biological processmonoacylglycerol catabolic process
GO_0045907Biological processpositive regulation of vasoconstriction
GO_0019369Biological processarachidonic acid metabolic process
GO_0009062Biological processfatty acid catabolic process
GO_0031090Cellular componentorganelle membrane
GO_0005856Cellular componentcytoskeleton
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004040Molecular functionamidase activity
GO_0047372Molecular functionacylglycerol lipase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0017064Molecular functionfatty acid amide hydrolase activity
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene nameFAAH
Protein nameFatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1)
Fatty acid amide hydrolase
SynonymsFAAH1
DescriptionFUNCTION: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules . Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates . It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) . FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). .

AccessionsO00519
A0A087WYA0
ENST00000243167.9
ENST00000484697.5