EZHIP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EZHIP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EZHIP at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0040029Biological processepigenetic regulation of gene expression
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0180000Molecular functionhistone methyltransferase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEZHIP
Protein nameEZH inhibitory protein
SynonymsCXorf67
DescriptionFUNCTION: Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) . Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 . Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). .

AccessionsQ86X51
ENST00000342995.4