EXO5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EXO5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EXO5 at tissue level.

III. Associated gene sets

GO_0036297Biological processinterstrand cross-link repair
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0045145Molecular functionsingle-stranded DNA 5'-3' DNA exonuclease activity
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0046872Molecular functionmetal ion binding
GO_0008310Molecular functionsingle-stranded DNA 3'-5' DNA exonuclease activity

IV. Literature review

[source]
Gene nameEXO5
Protein nameExonuclease V
Exonuclease V (Exo V) (hExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog)
SynonymsC1orf176
DEM1
DescriptionFUNCTION: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. .

AccessionsENST00000432259
ENST00000432259.6
ENST00000420209.2
X6RCY3
ENST00000420209
ENST00000372703.1
ENST00000418186.2
X6RLK1
X6RF29
ENST00000415550
ENST00000415550.6
ENST00000418186
ENST00000443729.6
ENST00000419161
Q9H790
ENST00000443729
ENST00000296380.9
X6RCL8
ENST00000358527.6
ENST00000682383.1
X6RK18
ENST00000419161.2