ETAA1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ETAA1 at tissue level.

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0031297Biological processreplication fork processing
GO_0006281Biological processDNA repair
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0043596Cellular componentnuclear replication fork
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameETAA1
Protein nameEwing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16)
ETAA1 activator of ATR kinase
SynonymsETAA16
DescriptionFUNCTION: Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity . Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 . Probably only regulates a subset of ATR targets . .

AccessionsA0A2R8Y6Y8
ENST00000272342.6
ENST00000644028.1
Q9NY74
A0A2R8YEV8
ENST00000645739.1
A0A2R8Y7B6
ENST00000462772.2