ERVFRD-1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ERVFRD-1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ERVFRD-1 at tissue level.

III. Associated gene sets

GO_0007520Biological processmyoblast fusion
GO_0006949Biological processsyncytium formation
GO_0000768Biological processsyncytium formation by plasma membrane fusion
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERVFRD-1
Protein nameSyncytin-2 (Endogenous retrovirus group FRD member 1) (Envelope polyprotein) (HERV-FRD) (HERV-FRD_6p24.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
SynonymsUNQ6191/PRO20218
ERVFRDE1
DescriptionFUNCTION: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process . .; FUNCTION: Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane . .

AccessionsENST00000472091.2
ENST00000542862.1
P60508