I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 28% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 28% ± 5% |
Insufficient scRNA-seq data for expression of EPPIN at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 97% | 64.22 | 635 / 653 | 1% | 0.04 | 8 / 605 |
| lung | 71% | 42.52 | 411 / 578 | 1% | 0.03 | 15 / 1155 |
| prostate | 64% | 16.16 | 158 / 245 | 0% | 0.00 | 1 / 502 |
| kidney | 51% | 5.61 | 45 / 89 | 0% | 0.00 | 2 / 901 |
| brain | 40% | 3.27 | 1066 / 2642 | 0% | 0 | 0 / 705 |
| bladder | 33% | 1.86 | 7 / 21 | 0% | 0.01 | 2 / 504 |
| uterus | 32% | 20.01 | 55 / 170 | 1% | 0.02 | 5 / 459 |
| intestine | 31% | 2.82 | 300 / 966 | 1% | 0.02 | 4 / 527 |
| breast | 30% | 4.48 | 138 / 459 | 1% | 0.03 | 6 / 1118 |
| adipose | 30% | 9.32 | 365 / 1204 | 0% | 0 | 0 / 0 |
| skin | 30% | 3.33 | 547 / 1809 | 0% | 0 | 0 / 472 |
| ovary | 22% | 6.88 | 40 / 180 | 6% | 0.11 | 25 / 430 |
| blood vessel | 10% | 0.91 | 135 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 10% | 0.75 | 35 / 359 | 0% | 0.01 | 1 / 286 |
| esophagus | 9% | 1.16 | 137 / 1445 | 1% | 0.01 | 1 / 183 |
| pancreas | 9% | 0.56 | 31 / 328 | 0% | 0 | 0 / 178 |
| liver | 8% | 1.88 | 17 / 226 | 0% | 0 | 0 / 406 |
| heart | 7% | 0.81 | 63 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 7% | 0.55 | 17 / 258 | 0% | 0 | 0 / 230 |
| spleen | 5% | 0.42 | 11 / 241 | 0% | 0 | 0 / 0 |
| muscle | 4% | 1.25 | 34 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 4% | 0.31 | 38 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010466 | Biological process | negative regulation of peptidase activity |
| GO_0090281 | Biological process | negative regulation of calcium ion import |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_1901318 | Biological process | negative regulation of flagellated sperm motility |
| GO_0005615 | Cellular component | extracellular space |
| GO_0009986 | Cellular component | cell surface |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0097524 | Cellular component | sperm plasma membrane |
| GO_0001669 | Cellular component | acrosomal vesicle |
| GO_0004867 | Molecular function | serine-type endopeptidase inhibitor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EPPIN |
| Protein name | Eppin (Cancer/testis antigen 71) (CT71) (Epididymal protease inhibitor) (Protease inhibitor WAP7) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) Epididymal peptidase inhibitor |
| Synonyms | WFDC7 WAP7 SPINLW1 |
| Description | FUNCTION: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. . |
| Accessions | O95925 ENST00000354280.9 [O95925-1] ENST00000409554.1 ENST00000336443.3 [O95925-2] ENST00000504988.1 [O95925-3] B7ZBA9 |
