EPOP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EPOP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EPOP at tissue level.

III. Associated gene sets

GO_0048863Biological processstem cell differentiation
GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0048663Biological processneuron fate commitment
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0035098Cellular componentESC/E(Z) complex
GO_0005694Cellular componentchromosome
GO_0070449Cellular componentelongin complex
GO_0044877Molecular functionprotein-containing complex binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameEPOP
Protein nameElongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28)
SynonymsC17orf96
PRR28
DescriptionFUNCTION: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. .

AccessionsA6NHQ4
ENST00000613024.2
ENST00000621654.2