EPHB3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EPHB3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EPHB3 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0048013Biological processephrin receptor signaling pathway
GO_0060997Biological processdendritic spine morphogenesis
GO_0001655Biological processurogenital system development
GO_0022407Biological processregulation of cell-cell adhesion
GO_0007413Biological processaxonal fasciculation
GO_0060021Biological processroof of mouth development
GO_0021952Biological processcentral nervous system projection neuron axonogenesis
GO_0060996Biological processdendritic spine development
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0043087Biological processregulation of GTPase activity
GO_0048538Biological processthymus development
GO_0022038Biological processcorpus callosum development
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0051965Biological processpositive regulation of synapse assembly
GO_0048546Biological processdigestive tract morphogenesis
GO_0016477Biological processcell migration
GO_0007411Biological processaxon guidance
GO_0050770Biological processregulation of axonogenesis
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0008046Molecular functionaxon guidance receptor activity
GO_0005003Molecular functionephrin receptor activity
GO_0005005Molecular functiontransmembrane-ephrin receptor activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEPHB3
Protein nameEphrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)
SynonymsETK2
HEK2
TYRO6
DescriptionFUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. .

AccessionsENST00000330394.3
P54753