ENPP6 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	5 studies	35% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ENPP6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	92%	676.42	2430 / 2642	92%	9.80	649 / 705
prostate	89%	288.32	217 / 245	58%	1.87	293 / 502
kidney	97%	813.93	86 / 89	18%	0.76	161 / 901
ovary	98%	993.92	176 / 180	17%	0.57	71 / 430
spleen	81%	94.97	195 / 241	0%	0	0 / 0
esophagus	56%	111.99	803 / 1445	13%	0.41	24 / 183
bladder	57%	106.48	12 / 21	6%	0.17	30 / 504
adrenal gland	33%	70.20	86 / 258	25%	1.94	57 / 230
intestine	54%	71.72	517 / 966	4%	0.08	23 / 527
breast	36%	50.85	164 / 459	16%	0.38	180 / 1118
stomach	28%	31.65	101 / 359	8%	0.26	22 / 286
uterus	16%	16.42	27 / 170	19%	0.72	85 / 459
tonsil	0%	0	0 / 0	31%	2.37	14 / 45
blood vessel	28%	40.71	370 / 1335	0%	0	0 / 0
lung	11%	15.28	62 / 578	8%	0.44	91 / 1155
thymus	15%	26.28	97 / 653	3%	0.15	19 / 605
liver	1%	0.77	2 / 226	13%	0.81	53 / 406
lymph node	0%	0	0 / 0	14%	0.35	4 / 29
adipose	12%	18.71	148 / 1204	0%	0	0 / 0
pancreas	0%	0.46	1 / 328	12%	0.22	21 / 178
skin	2%	1.21	28 / 1809	6%	0.27	29 / 472
peripheral blood	4%	3.56	38 / 929	0%	0	0 / 0
muscle	4%	3.11	30 / 803	0%	0	0 / 0
heart	1%	0.83	11 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.01	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006629	Biological process	lipid metabolic process
GO_0019695	Biological process	choline metabolic process
GO_0046475	Biological process	glycerophospholipid catabolic process
GO_0098552	Cellular component	side of membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0008889	Molecular function	glycerophosphodiester phosphodiesterase activity
GO_0047390	Molecular function	glycerophosphocholine cholinephosphodiesterase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0008081	Molecular function	phosphoric diester hydrolase activity

Gene name	ENPP6
Protein name	glycerophosphocholine cholinephosphodiesterase (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) Alternative protein ENPP6 Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)
Synonyms	UNQ1889/PRO4334
Description	FUNCTION: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells . Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity). .
Accessions	ENST00000512353.1 ENST00000296741.7 D6R9P1 L8ECN5 Q6UWR7

ENPP6 report