ENKD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ENKD1 at tissue level.

III. Associated gene sets

GO_1905515Biological processnon-motile cilium assembly
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0044458Biological processmotile cilium assembly
GO_0005814Cellular componentcentriole
GO_0097546Cellular componentciliary base
GO_0005813Cellular componentcentrosome
GO_0097731Cellular component9+0 non-motile cilium
GO_0036064Cellular componentciliary basal body
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005881Cellular componentcytoplasmic microtubule
GO_0000922Cellular componentspindle pole
GO_0043014Molecular functionalpha-tubulin binding
GO_0005515Molecular functionprotein binding
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameENKD1
Protein nameEnkurin domain containing 1
Enkurin domain-containing protein 1
SynonymsUNQ6410/PRO21183
C16orf48
DescriptionFUNCTION: Microtubule-binding protein which regulates microtubule organization and stability . Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle . This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia . Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis . .

AccessionsENST00000602644.5
R4GN60
A0A087X0D0
Q9H0I2
ENST00000602409.2
ENST00000243878.9 [Q9H0I2-1]