EMC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0045050Biological processprotein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO_0032991Cellular componentprotein-containing complex
GO_0072546Cellular componentEMC complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032977Molecular functionmembrane insertase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEMC1
Protein nameER membrane protein complex subunit 1
SynonymsKIAA0090
PSEC0263
DescriptionFUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). .

AccessionsENST00000488681.2
A0A8I5KW55
ENST00000375208.7 [Q8N766-4]
ENST00000690823.1
ENST00000690732.1
ENST00000688332.1
ENST00000688219.1
ENST00000475079.1
ENST00000486405.2
H7C5A2
A0A8I5KWE3
A0A8I5KTE8
ENST00000685594.1
H7C4E3
ENST00000692207.1
A0A8I5KSM5
ENST00000486238.1
A0A8I5KQA0
A0A8I5KRL9
A0A8I5KXE1
Q5TG59
ENST00000477853.6 [Q8N766-1]
ENST00000688667.1
A0A8I5QKP5
ENST00000375199.7 [Q8N766-2]
ENST00000685099.1
ENST00000688538.1
A0A8I5KWP6
ENST00000494770.7
Q8N766