ELP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002098Biological processtRNA wobble uridine modification
GO_0002926Biological processtRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO_0006417Biological processregulation of translation
GO_0005829Cellular componentcytosol
GO_0033588Cellular componentelongator holoenzyme complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameELP1
Protein nameAlternative protein IKBKAP
IkappaB kinase complex-associated protein
Elongator complex protein 1 (IkappaB kinase complex-associated protein)
Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150)
Elongator complex protein 1
SynonymsIKBKAP
IKAP
protein
variant
DescriptionFUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) . The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs . Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) . .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

AccessionsA0A6Q8PFB7
ENST00000675979.1
ENST00000675406.1
A0A6Q8PGC4
F5H2T0
ENST00000675711.1
ENST00000674948.1
A0A6Q8PG86
ENST00000537196.1
A0A6Q8PEX6
O95163
ENST00000675825.1
A0A6Q8PH48
ENST00000674938.1
A0A6Q8PFX1
ENST00000675893.1
ENST00000674890.1
ENST00000675765.1
H0YDF3
A0A6Q8PGA6
A0A6Q8PH36
ENST00000374647.10
A0A6Q8PHF4
ENST00000675321.1
A0A6Q8PHC9
A0A6Q8PGW3
A0A6Q8PHA0
A0A6Q8PFH9
A0A6Q8PF66
ENST00000495759.6
ENST00000675078.1
ENST00000675335.1
ENST00000674535.1
ENST00000676416.1
ENST00000675535.1
ENST00000675052.1
A0A6Q8PFC8
ENST00000676044.1
ENST00000675215.1
A0A6Q8PFN8
L8E918
ENST00000675727.1
Q4LE38
A0A6Q8PGR0
Q8N516
A0A6Q8PF69
ENST00000675458.1
ENST00000676237.1
A0A6Q8PHI5