ELL3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ELL3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ELL3 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0007283Biological processspermatogenesis
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0050769Biological processpositive regulation of neurogenesis
GO_0006354Biological processDNA-templated transcription elongation
GO_0061351Biological processneural precursor cell proliferation
GO_0042795Biological processsnRNA transcription by RNA polymerase II
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0072089Biological processstem cell proliferation
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_2000179Biological processpositive regulation of neural precursor cell proliferation
GO_1902166Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0048863Biological processstem cell differentiation
GO_0010717Biological processregulation of epithelial to mesenchymal transition
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0008023Cellular componenttranscription elongation factor complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030054Cellular componentcell junction
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameELL3
Protein nameRNA polymerase II elongation factor ELL3
Elongation factor for RNA polymerase II 3
Synonyms
DescriptionFUNCTION: Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III . .

AccessionsC9JHD8
Q9HB65
ENST00000319359.8 [Q9HB65-1]
ENST00000433927.1