EIPR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905281Biological processpositive regulation of retrograde transport, endosome to Golgi
GO_2001137Biological processpositive regulation of endocytic recycling
GO_0016567Biological processprotein ubiquitination
GO_0050796Biological processregulation of insulin secretion
GO_0032456Biological processendocytic recycling
GO_0005802Cellular componenttrans-Golgi network
GO_0000938Cellular componentGARP complex
GO_1990745Cellular componentEARP complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIPR1
Protein nameEARP complex and GARP complex interacting protein 1
EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein)
SynonymsTSSC1
DescriptionFUNCTION: Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network . Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex . Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). .

AccessionsQ53HC9
ENST00000382125.9
ENST00000444776.1
F8WB12
C9J0U9
F8WDS8
ENST00000455162.5
D3YTH5
ENST00000435721.5
ENST00000406835.6
C9JVR6
ENST00000398659.8
ENST00000443925.6
ENST00000441271.1
A8MUM1
F8WDX0