EIF5AL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EIF5AL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EIF5AL1 at tissue level.

III. Associated gene sets

GO_0045905Biological processpositive regulation of translational termination
GO_0006414Biological processtranslational elongation
GO_0045901Biological processpositive regulation of translational elongation
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0043022Molecular functionribosome binding
GO_0003746Molecular functiontranslation elongation factor activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEIF5AL1
Protein nameEukaryotic translation initiation factor 5A-1-like (eIF-5A-1-like) (eIF-5A1-like) (Eukaryotic initiation factor 5A isoform 1-like)
Synonyms
DescriptionFUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). .

AccessionsQ6IS14
ENST00000520547.4