EIF4EBP3 | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	4 studies	21% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of EIF4EBP3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	948.06	180 / 180	99%	10.95	427 / 430
prostate	100%	1508.86	245 / 245	98%	5.21	494 / 502
kidney	100%	1129.94	89 / 89	97%	4.39	873 / 901
thymus	100%	1272.28	653 / 653	95%	3.35	575 / 605
brain	97%	432.04	2569 / 2642	92%	2.68	651 / 705
intestine	100%	1190.36	966 / 966	88%	5.36	464 / 527
stomach	100%	1343.96	359 / 359	87%	4.66	248 / 286
pancreas	100%	884.87	328 / 328	87%	2.53	154 / 178
liver	100%	905.65	226 / 226	84%	2.59	343 / 406
breast	100%	1443.83	459 / 459	84%	2.71	936 / 1118
esophagus	100%	1039.69	1445 / 1445	77%	1.64	141 / 183
skin	99%	1205.10	1794 / 1809	77%	2.38	363 / 472
uterus	100%	814.65	170 / 170	70%	1.73	322 / 459
lung	100%	1022.74	577 / 578	65%	1.44	747 / 1155
bladder	100%	1061.67	21 / 21	63%	3.02	319 / 504
adrenal gland	100%	1961.94	258 / 258	60%	1.37	137 / 230
adipose	100%	1291.00	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	14.92	80 / 80
muscle	100%	1994.79	803 / 803	0%	0	0 / 0
spleen	100%	1319.78	241 / 241	0%	0	0 / 0
blood vessel	100%	715.94	1333 / 1335	0%	0	0 / 0
heart	98%	691.26	848 / 861	0%	0	0 / 0
peripheral blood	97%	658.37	902 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	73%	1.83	33 / 45
lymph node	0%	0	0 / 0	72%	1.67	21 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0045947	Biological process	negative regulation of translational initiation
GO_0016281	Cellular component	eukaryotic translation initiation factor 4F complex
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0030371	Molecular function	translation repressor activity
GO_0005515	Molecular function	protein binding
GO_0008190	Molecular function	eukaryotic initiation factor 4E binding

Gene name	EIF4EBP3
Protein name	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)
Synonyms
Description	FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export . .
Accessions	O60516 ENST00000310331.3

EIF4EBP3 report