EFNA4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EFNA4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EFNA4 at tissue level.

III. Associated gene sets

GO_0048013Biological processephrin receptor signaling pathway
GO_0007267Biological processcell-cell signaling
GO_0007411Biological processaxon guidance
GO_0098552Cellular componentside of membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005005Molecular functiontransmembrane-ephrin receptor activity
GO_0005515Molecular functionprotein binding
GO_0046875Molecular functionephrin receptor binding

IV. Literature review

[source]
Gene nameEFNA4
Protein nameEphrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
SynonymsEPLG4
LERK4
DescriptionFUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

AccessionsENST00000359751.8 [P52798-2]
ENST00000368409.8 [P52798-1]
P52798
ENST00000427683.2 [P52798-3]