EFNA3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EFNA3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EFNA3 at tissue level.

III. Associated gene sets

GO_0045664Biological processregulation of neuron differentiation
GO_0048013Biological processephrin receptor signaling pathway
GO_0007267Biological processcell-cell signaling
GO_0007411Biological processaxon guidance
GO_1902961Biological processpositive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO_0016525Biological processnegative regulation of angiogenesis
GO_0098552Cellular componentside of membrane
GO_0005886Cellular componentplasma membrane
GO_0005005Molecular functiontransmembrane-ephrin receptor activity
GO_0005515Molecular functionprotein binding
GO_0046875Molecular functionephrin receptor binding

IV. Literature review

[source]
Gene nameEFNA3
Protein nameEphrin-A3 (EFL-2) (EHK1 ligand) (EHK1-L) (EPH-related receptor tyrosine kinase ligand 3) (LERK-3)
SynonymsLERK3
EFL2
EPLG3
DescriptionFUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). .

AccessionsP52797
ENST00000368408.4 [P52797-1]