EEF1AKMT3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EEF1AKMT3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EEF1AKMT3 at tissue level.

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0018022Biological processpeptidyl-lysine methylation
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042054Molecular functionhistone methyltransferase activity
GO_0031072Molecular functionheat shock protein binding
GO_0008168Molecular functionmethyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity

IV. Literature review

[source]
Gene nameEEF1AKMT3
Protein nameEEF1A lysine methyltransferase 3 (EC 2.1.1.-) (Hepatocellular carcinoma-associated antigen 557a) (Methyltransferase-like protein 21B) (Protein-lysine methyltransferase METTL21B) (eEF1A-KMT3)
EEF1A lysine methyltransferase 3
SynonymsFAM119B
METTL21B
HCA557A
DescriptionFUNCTION: Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. .

AccessionsF8VZI8
ENST00000300209.13 [Q96AZ1-1]
F8W226
ENST00000333012.5 [Q96AZ1-2]
ENST00000548256.5
Q96AZ1
ENST00000551420.1