ECD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0048144Biological processfibroblast proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0035035Molecular functionhistone acetyltransferase binding

IV. Literature review

[source]
Gene nameECD
Protein nameEcdysoneless cell cycle regulator
Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1)
Synonyms
DescriptionFUNCTION: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP . May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes . Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins . The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex . May play a role in regulation of pre-mRNA splicing . .

AccessionsENST00000453402.5
C9JGV1
ENST00000454759.6 [O95905-2]
ENST00000494307.1
O95905
S4R458
ENST00000372979.9 [O95905-1]
ENST00000430082.6 [O95905-3]
F2Z2R1
C9J316
ENST00000484976.6
ENST00000413026.1