DUSP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0050868Biological processnegative regulation of T cell activation
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0050922Biological processnegative regulation of chemotaxis
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0046329Biological processnegative regulation of JNK cascade
GO_0016311Biological processdephosphorylation
GO_0051893Biological processregulation of focal adhesion assembly
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0120183Biological processpositive regulation of focal adhesion disassembly
GO_0030336Biological processnegative regulation of cell migration
GO_1990264Biological processpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO_0001772Cellular componentimmunological synapse
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0017018Molecular functionmyosin phosphatase activity
GO_0019901Molecular functionprotein kinase binding
GO_0008138Molecular functionprotein tyrosine/serine/threonine phosphatase activity
GO_0033549Molecular functionMAP kinase phosphatase activity
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0016791Molecular functionphosphatase activity
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameDUSP3
Protein nameDual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)
Dual specificity phosphatase 3
protein-serine/threonine phosphatase (EC 3.1.3.16)
Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48)
SynonymsVHR
DescriptionFUNCTION: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. .

FUNCTION: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. .

FUNCTION: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. .

AccessionsENST00000590342.1
P51452
ENST00000226004.8 [P51452-1]
ENST00000590935.1
ENST00000590753.1
K7ELG5
K7EPK5
K7ES89
B5BUI8