DUSP29 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DUSP29 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DUSP29 at tissue level.

III. Associated gene sets

GO_0043409Biological processnegative regulation of MAPK cascade
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0006470Biological processprotein dephosphorylation
GO_0042593Biological processglucose homeostasis
GO_0042692Biological processmuscle cell differentiation
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0004725Molecular functionprotein tyrosine phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0008138Molecular functionprotein tyrosine/serine/threonine phosphatase activity
GO_0033549Molecular functionMAP kinase phosphatase activity

IV. Literature review

[source]
Gene nameDUSP29
Protein nameDual specificity phosphatase 29 (Dual specificity phosphatase 27) (Dual specificity phosphatase DUPD1) (EC 3.1.3.16, EC 3.1.3.48)
SynonymsDUSP27
DUPD1
DescriptionFUNCTION: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate . Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (By similarity). Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity). .

AccessionsENST00000625469.1
ENST00000338487.6
Q68J44