I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 13 studies | 31% ± 8% | |
| glutamatergic neuron | 3 studies | 25% ± 6% | |
| type I pneumocyte | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 13 studies | 31% ± 8% | |
| glutamatergic neuron | 3 studies | 25% ± 6% | |
| type I pneumocyte | 3 studies | 18% ± 2% |
Insufficient scRNA-seq data for expression of DUSP18 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 186.80 | 1441 / 1445 | 100% | 7.26 | 183 / 183 |
| intestine | 100% | 240.39 | 964 / 966 | 100% | 6.54 | 526 / 527 |
| stomach | 99% | 130.45 | 355 / 359 | 100% | 7.23 | 285 / 286 |
| lung | 100% | 354.13 | 578 / 578 | 98% | 3.88 | 1134 / 1155 |
| breast | 100% | 175.09 | 457 / 459 | 98% | 3.17 | 1098 / 1118 |
| bladder | 100% | 164.95 | 21 / 21 | 97% | 3.93 | 491 / 504 |
| brain | 99% | 139.83 | 2606 / 2642 | 98% | 3.47 | 694 / 705 |
| skin | 100% | 231.40 | 1808 / 1809 | 97% | 3.03 | 458 / 472 |
| ovary | 96% | 100.48 | 173 / 180 | 99% | 4.09 | 427 / 430 |
| pancreas | 95% | 92.10 | 313 / 328 | 99% | 3.92 | 176 / 178 |
| thymus | 100% | 190.02 | 652 / 653 | 94% | 1.99 | 570 / 605 |
| uterus | 100% | 194.64 | 170 / 170 | 94% | 2.62 | 431 / 459 |
| kidney | 100% | 155.24 | 89 / 89 | 92% | 2.63 | 831 / 901 |
| adrenal gland | 97% | 114.91 | 250 / 258 | 73% | 1.34 | 168 / 230 |
| prostate | 100% | 161.06 | 244 / 245 | 68% | 1.09 | 341 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 2.93 | 29 / 29 |
| spleen | 100% | 201.66 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.22 | 1 / 1 |
| adipose | 99% | 168.16 | 1193 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 118.98 | 1307 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 258.56 | 907 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 2.47 | 41 / 45 |
| heart | 89% | 74.22 | 762 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 73% | 1.14 | 58 / 80 |
| liver | 38% | 21.52 | 86 / 226 | 27% | 0.57 | 110 / 406 |
| muscle | 35% | 18.13 | 279 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0035970 | Biological process | peptidyl-threonine dephosphorylation |
| GO_0035335 | Biological process | peptidyl-tyrosine dephosphorylation |
| GO_0016311 | Biological process | dephosphorylation |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0017017 | Molecular function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| GO_0016791 | Molecular function | phosphatase activity |
| GO_0008138 | Molecular function | protein tyrosine/serine/threonine phosphatase activity |
| GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
| GO_0017018 | Molecular function | myosin phosphatase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DUSP18 |
| Protein name | Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 20) (LMW-DSP20) Dual specificity phosphatase 18 Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) |
| Synonyms | LMWDSP20 |
| Description | FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). . FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). . |
| Accessions | ENST00000430175.5 ENST00000407308.1 ENST00000403268.1 F2Z2P2 ENST00000342474.4 F8VX42 ENST00000442752.1 ENST00000404885.5 H7C401 ENST00000377087.3 ENST00000334679.4 C9JEE9 Q8NEJ0 |
