DTX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0007219Biological processNotch signaling pathway
GO_0005737Cellular componentcytoplasm
GO_0016740Molecular functiontransferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDTX3
Protein nameDeltex E3 ubiquitin ligase 3 isoform C (EC 2.3.2.27)
Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)
E3 ubiquitin-protein ligase (EC 2.3.2.27)
Deltex E3 ubiquitin ligase 3
SynonymsRNF154
DescriptionFUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. .

AccessionsENST00000549583.5
A0A346B4X6
ENST00000551835.5
F8VV96
ENST00000548198.5 [Q8N9I9-1]
ENST00000550300.1
ENST00000337737.8 [Q8N9I9-1]
ENST00000548804.5 [Q8N9I9-1]
F8VUZ4
ENST00000550596.5
ENST00000551632.1 [Q8N9I9-2]
A0A1Y8EH36
Q8N9I9
ENST00000548478.1
A0A0C4DGI8
H0YHF9