DTX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0007219Biological processNotch signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0031965Cellular componentnuclear membrane
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameDTX2
Protein nameDeltex 2 transcript E
Deltex E3 ubiquitin ligase 2
Probable E3 ubiquitin-protein ligase DTX2
Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)
Deltex 2 transcript I
E3 ubiquitin-protein ligase (EC 2.3.2.27)
SynonymsRNF58
KIAA1528
DescriptionFUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

AccessionsENST00000435251.2
ENST00000631991.1
ENST00000456590.5
Q4FEB4
ENST00000633541.1
ENST00000435861.1
E7ET89
ENST00000442516.1
ENST00000446820.6 [Q86UW9-2]
Q6P2H0
ENST00000631700.1
C9JS11
C9JY61
ENST00000425780.5
ENST00000423646.5
ENST00000413936.6 [Q86UW9-1]
C9JVC8
C9IYX1
C9JF39
ENST00000631645.1
ENST00000438930.5
ENST00000634040.1
A0A0J9YXJ6
ENST00000430490.7 [Q86UW9-1]
C9JLU8
ENST00000446600.5
ENST00000457529.5
C9JEH4
Q75MM6
ENST00000451769.5
Q86UW9
Q4FEB2
ENST00000324432.9 [Q86UW9-1]
C9JII1
H7C3B8
ENST00000632696.1
ENST00000429179.1