DTD2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DTD2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DTD2 at tissue level.

III. Associated gene sets

GO_0106074Biological processaminoacyl-tRNA metabolism involved in translational fidelity
GO_0006399Biological processtRNA metabolic process
GO_0005737Cellular componentcytoplasm
GO_0106105Molecular functionAla-tRNA(Thr) hydrolase activity
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding
GO_0051500Molecular functionD-tyrosyl-tRNA(Tyr) deacylase activity

IV. Literature review

[source]
Gene nameDTD2
Protein nameD-aminoacyl-tRNA deacylase 2
D-aminoacyl-tRNA deacylase 2 (EC 3.1.1.96) (Animalia-specific tRNA deacylase) (ATD) (D-tyrosyl-tRNA(Tyr) deacylase 2) (L-alanyl-tRNA deacylase)
SynonymsC14orf126
DescriptionFUNCTION: Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS . Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site . Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity). .

AccessionsENST00000549850.1
Q96FN9
F8VVE1
ENST00000310850.9