DRG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901673Biological processregulation of mitotic spindle assembly
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0002181Biological processcytoplasmic translation
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0030955Molecular functionpotassium ion binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008017Molecular functionmicrotubule binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameDRG1
Protein nameDevelopmentally regulated GTP binding protein 1
Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)
Developmentally regulated GTP binding protein 1 (SFI1 centrin binding protein)
SynonymsNEDD3
SFI1
DescriptionFUNCTION: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP . Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions . When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation . Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions . .

AccessionsQ9Y295
F8WEE0
ENST00000416465.5
ENST00000548143.1
ENST00000331457.9
F8WBU4
ENST00000629688.1
H0YI06
ENST00000411518.5