DPYS | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell of proximal tubule	9 studies	40% ± 12%	Explore
hepatocyte	5 studies	71% ± 16%	Explore
glutamatergic neuron	3 studies	27% ± 4%	Explore

Name	Number of supported studies	Average coverage
kidney	3 studies	25% ± 10%	Explore
liver	3 studies	34% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	12612.60	226 / 226	90%	146.98	367 / 406
kidney	100%	5357.28	89 / 89	77%	36.55	698 / 901
adrenal gland	100%	537.91	258 / 258	47%	2.80	107 / 230
prostate	87%	263.95	214 / 245	31%	3.01	158 / 502
lung	85%	76.60	492 / 578	1%	0.21	17 / 1155
brain	68%	46.61	1788 / 2642	1%	0.04	5 / 705
adipose	64%	497.70	773 / 1204	0%	0	0 / 0
breast	52%	53.59	239 / 459	0%	0.02	3 / 1118
ovary	44%	18.17	79 / 180	2%	0.10	8 / 430
uterus	37%	15.66	63 / 170	1%	0.17	5 / 459
spleen	35%	23.89	84 / 241	0%	0	0 / 0
skin	17%	6.23	299 / 1809	3%	0.16	13 / 472
pancreas	13%	3.26	41 / 328	1%	0.08	2 / 178
intestine	10%	5.20	100 / 966	0%	0.19	2 / 527
peripheral blood	10%	8.24	96 / 929	0%	0	0 / 0
blood vessel	10%	3.57	133 / 1335	0%	0	0 / 0
stomach	8%	2.76	29 / 359	1%	0.03	2 / 286
esophagus	8%	2.38	113 / 1445	0%	0	0 / 183
thymus	2%	0.71	16 / 653	4%	2.30	26 / 605
bladder	5%	1.00	1 / 21	0%	0.02	1 / 504
muscle	3%	0.85	23 / 803	0%	0	0 / 0
heart	3%	1.30	23 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0046050	Biological process	UMP catabolic process
GO_0046079	Biological process	dUMP catabolic process
GO_0006212	Biological process	uracil catabolic process
GO_0006210	Biological process	thymine catabolic process
GO_0006248	Biological process	CMP catabolic process
GO_0006208	Biological process	pyrimidine nucleobase catabolic process
GO_0006249	Biological process	dCMP catabolic process
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0004157	Molecular function	dihydropyrimidinase activity
GO_0051219	Molecular function	phosphoprotein binding
GO_0005515	Molecular function	protein binding
GO_0042802	Molecular function	identical protein binding
GO_0008270	Molecular function	zinc ion binding

Gene name	DPYS
Protein name	Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) Dihydropyrimidinase
Synonyms
Description	FUNCTION: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Accessions	Q14117 E5RG28 H0YEV7 ENST00000533874.1 ENST00000351513.7 ENST00000521573.2

DPYS report