DPPA3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DPPA3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DPPA3 at tissue level.

III. Associated gene sets

GO_0044726Biological processepigenetic programing of female pronucleus
GO_0001939Cellular componentfemale pronucleus
GO_0001940Cellular componentmale pronucleus
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDPPA3
Protein nameDevelopmental pluripotency-associated protein 3 (Stella-related protein)
SynonymsSTELLAR
DescriptionFUNCTION: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization . In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process (By similarity). Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation (By similarity). Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark (By similarity). Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis (By similarity). May be important for the totipotent/pluripotent states continuing through preimplantation development (By similarity). Also involved in chromatin condensation in oocytogenesis (By similarity). .

AccessionsENST00000345088.3
Q6W0C5