DOHH | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	4 studies	20% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of DOHH at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	899.84	1445 / 1445	100%	25.10	183 / 183
uterus	100%	788.74	170 / 170	100%	32.19	458 / 459
thymus	100%	641.54	651 / 653	100%	22.74	604 / 605
brain	100%	1723.36	2640 / 2642	100%	31.82	702 / 705
liver	100%	539.86	225 / 226	100%	18.68	405 / 406
prostate	100%	802.08	245 / 245	99%	26.63	498 / 502
adrenal gland	100%	766.08	258 / 258	99%	24.98	228 / 230
intestine	100%	817.77	966 / 966	99%	29.23	522 / 527
ovary	100%	626.37	180 / 180	99%	14.89	425 / 430
kidney	100%	906.35	89 / 89	99%	20.64	890 / 901
skin	100%	1051.48	1808 / 1809	99%	30.02	466 / 472
bladder	100%	888.62	21 / 21	98%	30.05	494 / 504
pancreas	99%	438.82	324 / 328	99%	23.00	176 / 178
stomach	100%	669.33	358 / 359	98%	28.33	279 / 286
lung	99%	698.86	572 / 578	97%	19.54	1115 / 1155
breast	100%	710.12	459 / 459	95%	19.43	1057 / 1118
eye	0%	0	0 / 0	100%	37.80	80 / 80
lymph node	0%	0	0 / 0	100%	41.92	29 / 29
muscle	100%	1105.64	803 / 803	0%	0	0 / 0
spleen	100%	784.34	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.99	45 / 45
ureter	0%	0	0 / 0	100%	46.98	1 / 1
blood vessel	100%	698.10	1333 / 1335	0%	0	0 / 0
adipose	100%	711.40	1202 / 1204	0%	0	0 / 0
heart	97%	691.62	834 / 861	0%	0	0 / 0
peripheral blood	85%	486.90	794 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

Gene name	DOHH
Protein name	Deoxyhypusine hydroxylase Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1)
Synonyms	HLRC1
Description	FUNCTION: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine . Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity). .
Accessions	A0A5F9ZGM7 ENST00000427575.6 ENST00000671696.1 ENST00000672935.1 Q9BU89

GO_0008612	Biological process	peptidyl-lysine modification to peptidyl-hypusine
GO_0005575	Cellular component	cellular_component
GO_0005829	Cellular component	cytosol
GO_0019135	Molecular function	deoxyhypusine monooxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0005515	Molecular function	protein binding

DOHH report