DND1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DND1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DND1 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0060965Biological processnegative regulation of miRNA-mediated gene silencing
GO_0007281Biological processgerm cell development
GO_0048255Biological processmRNA stabilization
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameDND1
Protein nameDead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4)
SynonymsRBMS4
DescriptionFUNCTION: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). .

AccessionsENST00000542735.2
Q8IYX4