DNASE1L2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DNASE1L2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DNASE1L2 at tissue level.

III. Associated gene sets

GO_0006308Biological processDNA catabolic process
GO_0006259Biological processDNA metabolic process
GO_0003335Biological processcorneocyte development
GO_0001942Biological processhair follicle development
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004536Molecular functionDNA nuclease activity
GO_0005509Molecular functioncalcium ion binding
GO_0004530Molecular functiondeoxyribonuclease I activity

IV. Literature review

[source]
Gene nameDNASE1L2
Protein nameDeoxyribonuclease-1-like 2 (EC 3.1.21.-) (DNase I homolog protein DHP1) (Deoxyribonuclease I-like 2) (DNase I-like 2)
Deoxyribonuclease 1 like 2
SynonymsDHP1
DNAS1L2
DescriptionFUNCTION: Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells. .

AccessionsQ92874
H3BPU8
ENST00000569184.1
ENST00000567494.5 [Q92874-1]
ENST00000382437.8 [Q92874-2]
ENST00000564065.5 [Q92874-1]
ENST00000613572.4 [Q92874-2]
ENST00000320700.10 [Q92874-1]